Fructose-fused γ-butyrolactones and lactams, synthesis and biological evaluation as GABA receptor ligands

Abstract

We describe the synthesis of sugar-fused β-disubstituted γ-butyrolactones, γ-butyrolactams and a lipophilic β-disubstituted GABA analogue as potential GABA receptor ligands, where the pharmacophore is engineered into the carbohydrate scaffold in the form of a C-fructoside. The products were characterized for receptor binding studies of GABA A receptors.