Abstract
Abstract The reaction between a lithium enolate of an enantiomerically pure β‐hydroxyl carboxylate and an alkyl halide to give α‐alkyl‐β‐hydroxyl‐carboxylate with high diastereoselectivity (> 10:1 of anti ‐ preference) is generally known as the Fráter–Seebach alkylation. This reaction is found to be highly diastereoselective. The high diastereoselectivity is clearly evidenced in one experimental condition, in which only the anti ‐diasteromer forms.
Full Text 
Sign-in/Register to access full text options
Sign-in/Register to access full text options 
Published version (
Free)
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
