Fréquences géniques des systèmes HPA-1 et HPA-2 et risque potentiel d’allo-immunisation dans une population tunisienne

Abstract

Summary Allele and genotype frequencies of HPA-1 and HPA-2 systems in a Tunisian population were determined by polymerase chain reaction with sequence-specific primers (PCR-SSP) in 100 volunteer blood donors. The risk of allo-immunization in these systems has subsequently been evaluated. This work shows a higher HPA-1b (0.195) and HPA-2b (0.150) allelic frequency, which can be responsible for the potential risk of allo-immunization in HPA-1 and HPA-2 systems in case of pregnancy or transfusion.