Abstract
Based on experimental and clinical data, this review emphasizes the need for proper treatment of frostbite injuries. Experimentally employed anti-eicosanoid therapy in the modified Weatherly White model enhanced tissue survival, as each agent's inhibitory properties became more specific, when compared to controls. Topical methylprednisolone had a 17.5% tissue survival, while aspirin, Aloe vera cream and methimazole had 22.5%, 28.2% and 34.3% survival, respectively (p
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