Abstract
Frontotemporal lobe degeneration (FTLD) is the term currently used for what was formerly called Pick’s disease—a condition in which behavioral symptoms (of the frontal and/or temporal lobe syndrome) precede memory loss (1). Since Pick’s bodies are found in only 25% of patients with frontotemporal dementia, the diagnosis of Pick’s disease should be reserved for pathologically confirmed cases. From a clinical perspective these cases should be referred to as frontotemporal lobe degeneration (FTLD) or frontotemporal dementia (FTD). The diagnosis of FTLD is based mainly on the clinical presentation and can be confirmed by postmortem examination (1,2). The clinical diagnosis can be supported by the performance of structural as well as functional brain imaging.
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