Abstract
Background: Frontotemporal dementia (FDT) is related to memory and behavioral changes. There are variants in which the damage is more pronounced in one cognitive domain. Among the behavioral changes is the decision-making process. To evaluate this skill executive function tests are used, such as the Iowa Gambling Task (IGT). Objectives: Analyze the correlation between Iowa Gambling Task and decision- making process in patients with FDT. Methods: A review was conducted on PubMed, using the key words “Iowa Gambling Task AND Frontotemporal Dementia”, resulting in 4 papers. From those, 3 were included. Results: In Gleichgerrcht et al. (2012) IGT was used as a parameter to investigate risk taking on the decision-making process in patients with Primary Progressive Aphasia (PPA) and its subtypes (PPA is frequently associated with FTD) versus subjects with behavioral variant from FTD (bvFTD). PPA subjects had no improvement throughout the task, proving that there is an impairment in decision-making. The bvFTD group progression showed that this group has a tendency to choose risky behaviors, suggesting an inability to foresee negative outcomes. In Girardi, MacPherson & Abrahams (2011) the frontal variant was analyzed in subjects with ALS and had similar results, showing also a failure to learn how to avoid disadvantageous choices. Torralva et al. (2017) analyzed the results on subjects with the frontal variant in which the results were consistent with the previous studies analyzed in this review. Conclusion: In patients with FTD, the IGT proves that a cognitive impairment in the decision-making and risk-taking process is present.
Highlights
Capsaicin is able to induce mast cell degranulation, an event probably related to the pathophysiology of a migraine attack
The present review study aimed to address the mechanisms of action of capsaicin and other chemical inducers in mast cell degranulation and an interaction of nerves and events that happen in the dura mater with the activation of mast cells
Conclusion: the analyzed data indicate that the polymorphisms contributed to the susceptibility to Parkinson’s disease (PD), further studies related to the polymorphisms and their relationship to PD are still needed for more ethnic groups, and early diagnosis is possible
Summary
Capsaicin is able to induce mast cell degranulation, an event probably related to the pathophysiology of a migraine attack. Methods: A literature review and an observational, descriptive and transversal data collect on treatment for acute demyelinating polyradiculoneuritis, available at DATASUS from January 2008 to December 2020, and articles available at Scielo and PubMed. Results: There were 7,917 hospitalizations, representing a total expenditure of R$ 9,392,552.04, 2009 being the year with the highest number of hospitalizations (809) and 2017 with the highest amount spent during the period (R$ 967,284.65). Methods: A literature review and an observational, descriptive and transversal data collect on surgical treatment was carried out, available from January 2008 to December 2020 and articles available in Scielo, Lilacs and PubMed. Results: There were 15,148 hospitalizations for surgical procedures for the treatment of chronic subdural hematoma, representing a total expenditure of R$ 45,365,258.21, with 2018 being the year with the highest number of hospitalizations (1,418) and with the highest amount spent during the period (R$ 4,570,334.28). Conclusions: The “Coca-Cola Bottle sign” is a classic sign of Graves’ disease, some signs, such as, unilateral and single orbital musculature involvement, may be suggestive of involvement by other etiologies, suggesting the benefit of an early expanded investigation
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