Abstract
We present a review of the literature on the function of frontopolar cortex from the last 20 years, then support conclusions from it by presenting an original empirical study. Considerable research has focused in the last decade on a hierarchical organization of cognitive function in the frontal lobes, with simple motor response mapping occurring in the posterior areas of the frontal lobes, and increasingly abstract responses involving increasingly anterior regions. The frontopolar cortex (FPC), Brodmann's Area 10, is most often found to be recruited by the most abstract varieties of processing. We discuss the nature of abstractness or complexity by which these hierarchical schemes are defined. We then report our study whose results suggest that the anterior frontal lobe is not specialized for processing and responding about the most abstract information, but is recruited when one must manipulate relationally complex information. Simply encoding or maintaining abstract or complex information is accomplished by the dorsolateral prefrontal cortex (DLPFC). In the course of everyday reasoning, we must manipulate, rearrange, juxtapose, or restructure complex information. The ability to do this with complex information allows humans to navigate complex problems or situations better than higher primates. It permits the production of novel, complex solutions to complex challenges. Our results suggest that it is the frontal pole which is recruited when such manipulation and restructuring of represented information is needed.
Highlights
It is only in the last 20 years that frontopolar cortex (FPC) has been recognized as distinct anatomically and functionally from dorsolateral prefrontal cortex (DLPFC)
We review recent thinking about frontal lobe organization, evidence bringing it into question, and revisit an alternative view of FPC function
The purpose of this study was to separate and compare the demands placed on frontopolar cortex by representation of integrated information and manipulation of integrated information
Summary
It is only in the last 20 years that frontopolar cortex (FPC) has been recognized as distinct anatomically and functionally from dorsolateral prefrontal cortex (DLPFC). It has appeared to be recruited for complex or abstract cognition, and as a result has been thought to be responsible for the most sophisticated human understanding (Thiebaut de Schotten et al, 2017, #27). In this perspective article, we review recent thinking about frontal lobe organization, evidence bringing it into question, and revisit an alternative view of FPC function. Strong evidence of connected regions in the frontal cortex has been produced by examining connectivity patterns (Thiebaut de Schotten et al, 2017). These cortical areas may be part of cortico-striatal loops arranged hierarchically (Mestres-MissÈ et al, 2012; Korb et al, 2017; Rusu and Pennartz, 2019)
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