Abstract
This presentation will give an overview of the rapidly evolving field of genetics and clinical phenotypes of frontotemporal dementia. Frontotemporal dementia (FTD) is a spectrum of disorders that involve the frontal and/or temporal lobes. It is familial in 20-30%of cases and the frequency of major causative mutations differs with respect to geographical distribution. Whereas clinico-pathological relations in genetic forms of frontotemporal dementia are straight-forward and can be divided into tau-pathologies and TDP-43 pathologies, no such clear relationships have thus far been shown for sporadic cases of frontotemporal dementia.
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