Abstract
Lanthanide Probes Hydrogen sulfide (H2S) functions as a signaling second messenger, and inhibition of H2S-producing enzymes may be a promising therapeutic strategy. The emissive lanthanide probe LLPS-LnIII generates strong turn-on luminescence via a unique mechanism. H2S-mediated reduction of an aryl azide moiety triggers an intramolecular cyclization to form a chromophore that sensitizes TbIII or EuIII luminescence. Time-gated detection with LLPS-LnIII enabled high-throughput screening for inhibition of H2S-producing cystathionine γ-lyase. For more details, see the Communication by L. W. Miller et al. on page 752 ff.
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