Abstract
Profound pharmacological benefits can be provided by site-selective incorporation of the deuterated “magic methyl” group, which can be considered an important tool for drug optimization and development. This review highlights site-selective trideuteromethylation strategies according to the trideuteromethylation reagent used and describes the mechanism and scope of the reactions. As such, this review aims to be a guide for researchers, offering them the available C−CD3 formation strategies for the preparation of new or modified drugs or materials. For more details see the Review by M. Rueping et al. on page 11751 ff.
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