Abstract
The aldol-type reaction became one of the forefathers of C−C bond formation reactions. Advancements in the synthetic methodology resulted in the development of chemo-, regio-, and stereoselective processes. This Review focuses on reductive aldol-type alkylation methods implemented to the synthesis of ten approved drug substances. Furthermore, retrosynthetic analysis demonstrates that other active pharmaceutical ingredients could be obtained via reductive Aldol-type reactions. For more information, see the Review by S. Runikhina et al. on page 15327 ff.
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