Abstract
The Plasma Cells Granuloma is a relatively rare lesion, that forms a nodule or a mass, it is conformed of polyclonal plasmatic cells in storiform background fibrosis and spread of fusiform cells. We present the case of a 62-year-old woman, with a history of oophorectomy and increased volume in the right frontal area of the head, then presenting neurologic signs of frontal lobe syndrome. Radiologic images showed a wide right frontal lobe neoplasia that spreads diffusely. Histologically the tumor was formed by plasma cells, B lymphocytes infiltrate, and numerous blood vessels. It was positive for CD20, kappa, lambda, CD3, and CD4. Even though it is uncommon, it can develop at any place and must be included in the differential diagnoses list for plasma cells neoplasia. The positivity of light chains kappa and lambda make evident the polyclonality that confirms the diagnosis.
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