Abstract
ABSTRACT.Surgical treatment for frontal lobe epilepsy provides both a challenge in localization and an opportunity to better understand the pathophysiology of this condition. EEG localization is difficult because anatomic and pathophysiologic characteristics of the frontal lobe result in widespread and generalized epileptiform activity at the scalp, generated from more focal epileptogenic zones. Preoperative EEG investigation of 34 adults and 45 children, who had surgical removal of frontal lobe epileptogenic zones, reveals a continuum of interictal disturbances, ranging from focal abnormalities to lobar and multilobar epileptogene sis. The degree and direction of spread of epileptogenic activity varies widely with the location of the source and with the age of the patient. Correlation of EEG data with ancillary diagnostic procedures is crucial for proper interpretation.
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