Abstract
Investigators at Maastricht University Medical Center, and Epilepsy Center Kempenhaeghe, The Netherlands, using functional magnetic resonance imaging (fMRI), studied the relationship between brain activation, functional connectivity, and cognitive functioning in 32 children aged 8-13 years with frontal lobe epilepsy (FLE) and 41 healthy age-matched controls.
Highlights
During working memory task performance, children with frontal lobe epilepsy (FLE) showed a global decrease in functional brain connectivity compared to controls, whereas brain activation patterns remained intact
The decrease in frontal lobe connectivity in children with FLE complicated by cognitive impairment affected both connections within the frontal lobe and those from frontal to parietal and temporal lobes, cerebellum, and basal ganglia
The decrease in functional brain connectivity appeared to be related to the epilepsy itself, and was independent of cognitive performance
Summary
Investigators at Maastricht University Medical Center, and Epilepsy Center Kempenhaeghe, The Netherlands, using functional magnetic resonance imaging (fMRI), studied the relationship between brain activation, functional connectivity, and cognitive functioning in 32 children aged 8-13 years with frontal lobe epilepsy (FLE) and 41 healthy age-matched controls. Cognition was impaired in 16 children with FLE (50%) and in 3 healthy controls (7%). During working memory task performance, children with FLE showed a global decrease in functional brain connectivity compared to controls, whereas brain activation patterns remained intact.
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