Frontal and parietal lobes play crucial roles in understanding the disorder of consciousness: A perspective from electroencephalogram studies.

Abstract

Electroencephalogram (EEG) studies have established many characteristics relevant to consciousness levels of patients with disorder of consciousness (DOC). Although the frontal and parietal brain regions were often highlighted in DOC studies, their electro-neurophysiological roles in constructing human consciousness remain unclear because of the fragmented information from literatures and the complexity of EEG characteristics. Existing EEG studies of DOC patients were reviewed and summarized. Relevant findings and results about the frontal and parietal regions were filtered, compared, and concluded to clarify their roles in consciousness classification and outcomes. The evidence covers multi-dimensional EEG characteristics including functional connectivity, non-linear dynamics, spectrum power, transcranial magnetic stimulation-electroencephalography (TMS-EEG), and event-related potential. Electroencephalogram characteristics related to frontal and parietal regions consistently showed high relevance with consciousness: enhancement of low-frequency rhythms, suppression of high-frequency rhythms, reduction of dynamic complexity, and breakdown of networks accompanied with decreasing consciousness. Owing to the limitations of EEG, existing studies have not yet clarified which one between the frontal and parietal has priority in consciousness injury or recovery. Source reconstruction with high-density EEG, machine learning with large samples, and TMS-EEG mapping will be important approaches for refining EEG awareness locations.