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Abstract

We report on an attempt to increase the therapeutic effect of photodynamic therapy using a lipid nanoparticle (LNP). The findings indicate that the internal structure of the LNPs change depending on the amount of photosensitizer in the particle. The photoactivity and cell‐killing effect of photosensitizer also changed with increasing amount of cargo, suggesting that the internal structure of the LNP is an important factor that affect the therapeutic effect.Further details can be found in the article by Fumika Kubota, Satrialdi, Yuta Takano, Masatoshi Maeki, Manabu Tokeshi, Hideyoshi Harashima, and Yuma Yamada (e202200119). image