Abstract
Mol. Nutr. Food Res. 2022, 66, 202100732 DOI: 10.1002/mnfr.202100732 AMPK pathway plays vital role in the energy metabolism. Recent investigations indicate that AMPK is closely related with carcinogenesis. Polyphenols can target AMPK to promote apoptosis and cell cycle arrest of cancer cells. Besides interfering with classical carcinogenesis pathways such as MAPK, polyphenol can also target AMPK to exert anti-cancer effect by affecting energy metabolism of cancer cells. The novel mechanism will enhance the understanding of polyphenols, which benefits to develop functional foods and cancer prevention. This is reported by Feijun Luo and co-workers in article number 2100732.
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