Abstract
The Front Cover shows the structure of a peptido RNA that was prepared in NMR quantities from a peptide and an oligoribonucleotide in aqueous solution, without the need for protecting groups. The two-step protocol starts with conversion of the 5'-terminal phosphate of the RNA to an imidazolide, followed by 1-ethylimidazole-catalyzed coupling at pH 8 that produces the phosphoramidate-linked final product. The method opens the door to the systematic investigation of molecular hybrids implicated in the origin of RNA-directed protein synthesis. More information can be found in the Full Paper by C. Richert et al.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
