Front Cover: Synthesis of Difluoroglycine Derivatives from Amines, Difluorocarbene, and CO2: Computational Design, Scope, and Applications (Chem. Eur. J. 39/2021)

Abstract

An Artificial Force Induced Reaction (AFIR) on a super computer has led to a new three-component reaction (3CR) of amines, difluorocarbene, and the inexpensive and non-toxic C1 source CO2. This reaction produces a broad range of α,α-difluoroglycine derivatives that are bioisosteres of natural glycine. The versatility of these products is very broad; i.e., they can be used as new difluorocarbene sources, substrates for radical substitution reactions, and precursors for new NHC ligands. More information can be found in the Full Paper by S. Maeda, T. Mita et al. (DOI: 10.1002/chem.202100812).