Abstract
Membrane transporters are flexible proteins that cycle between structurally diverse conformations during transport. Yet, little is known about structural ensembles along transport paths, the transition speed between them, and particularly about the coupling between structures and transport. In this review the power of single-molecule FRET to answer some of these questions is highlighted and key studies on a broad variety of membranes transporters are discussed. More information can be found in the Mini Review by H. Hofmann, C. Löw et al.
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