Abstract
The Front Cover shows the development of a potent ligand for galectin-8 (in light blue), a protein produced by endothelial cells and involved in many processes, such as promoting angiogenesis. Starting from a 3-lactoylgalactoside (in pink), the best fit to complete the “puzzle of the binding” consisted of a molecule with a cyclohexyl moiety in position 3 of the galactose and a dichlorothiophenyl group in position 1. The new ligand showed an improved affinity of almost 200-fold, representing an optimal starting point for the development of high-affinity ligands for galectin-8, a promising target for cancer and diseases associated with bone loss and inflammation. Cover graphics by Benedetta Girardi, Department of Pharmaceutical Sciences, University of Basel. More information can be found in the Communication by Benedetta Girardi, Oliver Schwardt, Marko Anderluh et al.
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