Abstract
DOI: 10.1002/elps.202200028 The cover picture illustrates the first work screening prolyl hydroxylase 2 (PHD2) inhibitory activity from traditional Chinese medicines (TCMs). PHD2 is a key oxygen receptor participating in the regulation of oxygen homeostasis in the human body and thus, it is one of the crucial targets for drug discovery and development for hypoxia-based diseases. The present work utilizes the advantage of the high separation efficiency of the CZE-UV method to avoid the interference of the complex matrix on the results of inhibitor screening. Astragali Radix and Codonopsis pilosula were found to have good PHD2 inhibitory activities for the first time in PHD2 screening, suggesting their potential anti-hypoxic activities in oxygen-regulated pathways in vivo. The present work provides a novel approach for screening the PHD2 inhibitory activity of TCMs extracts and the discovery of anti-hypoxia bioactive compounds.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
