Front Cover: Protein Backbone Alteration in Non‐Hairpin β‐Turns: Impacts on Tertiary Folded Structure and Folded Stability (ChemBioChem 11/2023)

Abstract

Backbone modification in β-turns is vital in the development of protein mimetics. Prior work has focused on the subset of turns that join strands of a β-sheet. The cover image, rendered in a style inspired by Pittsburgh native Andy Warhol, depicts four modification schemes among a series examined in a helix-loop-helix domain. Optimal artificial residue placement yields variants of the prototype sequence with native-like tertiary structure and improved thermal stability. More information can be found in the Research Article by T. W. Harmon and W. S. Horne.