Abstract
The front cover picture, designed and donated by WesWizzArt and painted by the Mexican artist Way (Wayra Castillo-Guerrero), illustrates the toluene dioxygenase-catalyzed conversion of aromatics. The enzyme exhibits a high affinity for monocyclic, but only a low one for bicyclic substrates. A semi-rational designed mutant library opened the way for the conversion of the bicyclic substrates naphthalene, 1,2,3,4-tetrahydroquinoline and 2-phenylpyridine at unprecedented rates, enabling the biosynthesis of their products in substantial quantities. Variants at active site positions M220, A223 and F366 exhibited a major influence in product formation and selectivity. Details can be found in the Research Article by Bernhard Hauer and co-workers (J. L. Wissner, J. T. Schelle, W. Escobedo-Hinojosa, A. Vogel, B. Hauer, Adv. Synth. Catal. 2021, 363, 4905–4914; DOI: 10.1002/adsc.202100296).
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