Front Cover Picture: Haloalkenyl Imidoyl Halides as Multifacial Substrates in the Stereoselective Synthesis of N‐Alkenyl Compounds (Adv. Synth. Catal. 13/2021)

Abstract

The front cover picture illustrates the reaction of N-fluoroalkylated-1,2,3-triazoles with aluminum trihalide, proceeding via a vinyl cation (illustrated as the structure in brackets in the middle) to afford structurally diverse N-haloalkenyl imidoyl halides. These products are formed in a stereoselective fashion on both double bonds and have been utilized in the synthesis of various N-alkenyl compounds, such as enamides, enamidines, enimines, N-alkenyl tetrazoles, and other. In this work, Beier and co-workers show a new, mild and efficient 1,2,3-triazole denitrogenative ring-opening process mediated by easily available Lewis acids. Details can be found in the Full Paper by Beier and co-workers (A. Markos, L. Janecký, T. Chvojka, T. Martinek, H. Martinez-Seara, B. Klepetářová, P. Beier, Adv. Synth. Catal. 2021, 363, 3258–3266; DOI: 10.1002/adsc.202100009).