Front Cover Picture: Cu(I) Mediated Azidation of Halobenzenes, and Cu Catalysed Selective Azide Reduction to Corresponding Amines (Adv. Synth. Catal. 17/2022)

Abstract

The front cover image illustrates the complex mixture of a selective copper-mediated reaction of a bromobenzene bearing a bromoalkanoyl chain to an amine-azide. It proceeds stepwise via a bis-azide intermediate and produces copper nanostructures simultaneously, which grow on the PTFE stirring bar. The copper in the reaction mixture is responsible for the aryl azide reduction, and the mild protocol is broadly applicable for bromobenzenes with electron withdrawing groups. Furthermore, the copper nanostructures can mediate azide-alkyne click reactions. Details can be found in the Research Article by Max Roemer and co-workers (M. Roemer, I. Luck, N. Proschogo, Adv. Synth. Catal. 2022, 364, XXXX–XXXX; DOI: 10.1002/adsc.202200594)