Abstract
An iridium-catalyzed methodology leads to fully aliphatic tertiary amines starting from readily available ketones and amines. This direct reductive amination transformation, fueled by hydrogen similar to a space rocket, enables access to an unprecedented chemical space with a functional group relevance compatible with active pharmaceutical ingredients. More information can be found in the Research Article by M. Jouffroy, R. Gramage-Doria et al. (DOI: 10.1002/chem.202201078).
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