Front Cover: Furo[2,3‐d]pyrimidines as Mackinazolinone/Isaindigotone Analogs: Synthesis, Modification, Antitumor Activity, and Molecular Docking Study (Chem. Biodiversity 3/2023)

Abstract

Front Cover. Cancer has become a leading cause of death worldwide, oncology suggests chemotherapeutical drugs based on synthesized anticancer agents, phytomedicine, and metal complexes so far. On this basis, naturally-occurring alkaloids mackinazolinone and isaindigotone were as templates of target heterocycles, the synthesis of tricyclofuran[2,3-d]pyrimidine was studied under scaffold-hopping strategies, the synthesized compounds showed inhibitory effects on human cervical cancer HeLa and colon HT-29 cells. The results of molecular docking showed that the compounds with antitumor activity were well bound to the target EGFR protein and the matching degree was high, so the compounds have potential prospect, as reported by B. Song et al. in their research article at 10.1002/cbdv.202201059. 2023 VOLUME 20 NO. 3