Abstract
The Front Cover shows a macrophage being attacked by Leishmania parasites. Fortunately, fragment small-molecule “Fragman” comes to the rescue by defeating the malicious parasites and thus saving the grateful macrophage. This illustrates that fragment-based phenotypic lead discovery (FPLD) can serve as a rapid and practical strategy to generate leads for a wide array of drug discovery programs. The FPLD strategy combines aspects of phenotypic screening and fragment-based lead discovery and takes advantage of cell-permeability properties of small molecules. Cover art by Alan Rossi and Yann Ayotte. More information can be found in the Full Paper by Albert Descoteaux, Steven R. LaPlante et al. on page 1377 in Issue 14, 2018 (DOI: 10.1002/cmdc.201800161).
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