Front Cover: Druggability Assessment for Selected Serine Proteases in a Pharmaceutical Industry Setting (ChemMedChem 21/2020)

Abstract

The Front Cover shows the backbone representation of a protein structural ensemble for the serine protease FXa with a reticle pointing at it. The potential of targeting a protein with a drug-like molecule plays an important role in early drug discovery. In their study, the authors address the topic of target druggability assessment. They present key insights from high-throughput screening (HTS) and protein structure-based druggability assessments and illustrate that conformational variability matters. More information can be found in the Full Paper by Leon Wehrhan, Katharina Meier et al.