Abstract
Grignard reagents (R-Mg-X) are commercial carbon nucleophiles commonly used in organic synthesis, but their stability becomes a limitation for the least-reactive electrophiles. A bulky magnesium anilide additive (in purple) generates a new organometallic reagent (R−Mg-NHAr) in situ that boosts the nucleophilicity and selectivity of the organometallic ligand (in green). In the Research Article by A. Mendoza and co-workers (DOI: 10.1002/chem.202104053), these reagents prove to be instrumental in the direct synthesis of ketones from carboxylic acids, a transformation that was only possible with some organolithium reagents before.
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