Abstract
Grignard reagents (R-Mg-X) are commercial carbon nucleophiles commonly used in organic synthesis, but their stability becomes a limitation for the least-reactive electrophiles. A bulky magnesium anilide additive (in purple) generates a new organometallic reagent (R−Mg-NHAr) in situ that boosts the nucleophilicity and selectivity of the organometallic ligand (in green). In the Research Article by A. Mendoza and co-workers (DOI: 10.1002/chem.202104053), these reagents prove to be instrumental in the direct synthesis of ketones from carboxylic acids, a transformation that was only possible with some organolithium reagents before.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
