Abstract
The Front Cover shows the release of plasmid DNA to the cytoplasm from a core-shell nanoparticle (CSNP) consisting of a condensed nucleic acid core with protamine sulfate and a polymeric shell that is chemically tuned for facilitated escape from the mildly acidic endosome due to its varying protonation, acid-degradability, and membrane disruption capabilities. The transnuclear transport of the plasmid DNA is aided by protamine sulfate enabling efficient expression of the genetic payload. Cover design by Tae Won Yoon. More information can be found in the Research Article by Soo Kyung Cho, Young Jik Kwon et al.
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