Front Cover: Characterization of an Unusual α‐Oxoamine Synthase Off‐Loading Domain from a Cyanobacterial Type I Fatty Acid Synthase (ChemBioChem 18/2023)

Abstract

A new fatty acid synthase off-loading domain. Fatty acid synthase (FAS) usually releases its products by hydrolysis or transesterification. Here, an α-oxoamine synthase off-loading domain is identified in a cyanobacterial type I FAS. This domain releases the fatty acyl chain through a condensation with L-serine, offering a novel pathway to α-amino ketones that share similarities with sphingolipid precursors. More information can be found in the Research Article by A. E. Fraley, S. Sasso et al.