Front Cover: Base‐Mediated Remote Deuteration of N‐Heteroarenes – Broad Scope and Mechanism (Eur. J. Org. Chem. 19/2022)

Abstract

The Front Cover illustrates how the thermodynamic stability of intermediary anions governs selectivity in the remote base-mediated deuteration of pyridine derivatives. We have translated this insight from our mechanistic studies into a competition among weightlifters. The strongest weightlifters — i. e. the most stable anions — can lead to the best deuterium incorporation, which is why the C4 anion of our model substrate wins the competition and can lift the 4-deuterated pyridine. Cover idea by Jiali Liu, design by Ingrid Piehl. More information can be found in the Research Article by H. Jiao, H. Neumann, M. Beller et al.