Abstract
The front cover provided by the TheoCheM group from Vrije Universiteit Amsterdam shows the four primary interaction components (hydrogen bonding, cross-terms, base stacking, and solvation) that determine the stability of B-DNA duplexes. Quantum chemical analyses identify an interplay between the stabilizing hydrogen bonds between nucleotides that drive the formation of the DNA double-strand, and the destabilizing loss of stacking interactions within individual strands combined with partial desolvation. The sequence-dependence in the duplex stability originates mainly from the cross-terms which can be attractive or repulsive. More information on 10 years of ChemistryOpen can be found in the Research Article by Celine Nieuwland et al.
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