Abstract
Formaldehyde is a potent one-carbon electrophile for organic synthesis. However, there are few synthetic approaches using aqueous formaldehyde (formalin). This paper describes an organocatalyzed enantioselective α-hydroxymethylation of malonic diesters with aqueous formaldehyde. Formaldehyde would react catalytically by transferring from the aqueous phase to the organic phase, providing chiral versatile malonic diester derivatives which contain a quaternary stereogenic center. More information can be found in the Research Article by Takuya Kanemitsu et al.
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