Front Cover: Albumin Conjugates of Thiosemicarbazone and Imidazole‐2‐thione Prochelators: Iron Coordination and Antiproliferative Activity (ChemMedChem 18/2021)

Abstract

The Front Cover shows the bioconjugation of an antiproliferative prochelator to serum albumin via formation of a disulfide bond with a reduced cysteine on the protein. The abundance of albumin in blood is represented by the red background featuring red blood cells. The disulfide-masked prochelators of this class have antiproliferative activities at submicromolar levels in a panel of cancer cell lines. Cover design by Matthew W. Lluis. More information can be found in the Communication by Elisa Tomat et al..