Front Cover: A Systematic Review of Metabolic Alterations Underlying IgE‐Mediated Food Allergy in Children

Abstract

Mol. Nutr. Food Res. 2021, 65, 202100536 DOI: 10.1002/mnfr.202100536 IgE-mediated food allergies (IgE-FA) are considered a growing epidemic. Its pathogenic mechanisms remain however largely unknown. The authors performed a literature search followed by in-depth pathway mapping of IgE-FA in children, and revealed a shift in energy metabolism, next to aberrant metabolization of bile acids, lipids, nucleotides, fecal SCFAs and amino acids. As such, this work confirmed the unprecedented opportunities of metabolomics while offering a solid basis for future FA research. This is reported by Lynn Vanhaecke and co-workers in article number 2100536.