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Abstract
The Front Cover shows shows the influence of reaction solvent on the reaction of purin-2-yl Grignards with carbonyl compounds. In the ether (THF), the reaction gives 8-carbinol products due to a rapid isomerisation to the purin-8-yl, whereas performing the reaction in dichloromethane stops the isomerisation and yields 2-carbinols in good yields. In contrast to aldehydes, reactions with ketones require prior complexation with LaCl3.2LiCl before addition to the Grignard reagent. More information can be found in the Full Paper by M. R. Gordon, S. Gazzola et al.
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