Abstract
Evidence for parent-of-origin effects in multiple sclerosis (MS) development and in inheritance of experimental autoimmune encephalomyelitis (EAE), with 1/3 of the risk loci displaying an imprinting-like transmission, strongly suggest epigenetic involvement in MS pathogenesis. Using a whole genome approach, we here sought to identify epigenetically regulated genes that potentially underlie this contribution, in CD4+ T cells, one of the key players in MS disease. To identify imprinted genes, an EAE susceptible rat strain and an EAE resistant rat strain, single nucleotide polymorphisms (SNPs) segregating the two strains, were bred in a reciprocal manner.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
