From theory to bench confirmation or from bench to theory.

Pierre Asfar,Frauke Tillmans,Andreas Koch,Peter Radermacher,Julien Demiselle

doi:10.1186/s40635-016-0113-2

Abstract

In this commentary, the authors discuss two possible approaches in experimental studies. The first approach is to replicate an experimentation in order to confirm or not previously published results. The second one is more theoretical and consists in estimating the expected effect of all the components of the problem. When theoretical calculations suggest a theoretical failure that contradicts previous published results, investigators are between a rock and a hard place. Indeed, how can already published data and theoretical likelihood of failure be reconciled?

Highlights

In this commentary, the authors discuss two possible approaches in experimental studies
Correspondence The search for alternative routes to support oxygenation in case of severe lung failure is a very valuable concern in critical care medicine [1]. In such a desperate clinical situation, an alternative route should significantly contribute to oxygenation without further jeopardizing the patient
Intestinal oxygen administration was proposed as a possible alternative route to improve respiratory failure-induced cyanosis in human

Summary

Introduction

The authors discuss two possible approaches in experimental studies. Correspondence The search for alternative routes to support oxygenation in case of severe lung failure is a very valuable concern in critical care medicine [1]. In such a desperate clinical situation, an alternative route should significantly contribute to oxygenation without further jeopardizing the patient.

Results

Conclusion