Abstract

The most exciting phrase to hear in science, the one that heralds new discoveries, is not “Eureka!” but “That’s funny…"— Isaac Asimov Over the past quarter, we have seen rapid improvement in outcomes during this current pandemic. There are substantial data on the impact of masks, social distancing, and handwashing (see the impact of easing in public policy and rate of spread in countries such as the Netherlands and Cuba), and we have seen the impact of vaccination on improved outcomes (see the impact of increased coronavirus exposure on tragic outcomes such as death in high-vaccination countries such as the United Kingdom). We have a winning strategy for addressing the pandemic. When we overcome the pandemic will be determined by the recognition and application of effective methods applied worldwide. We have launched civilians into space. We continue to learn about the impacts and opportunities to address climate change. We have flown a helicopter on Mars. All scientific advances allow for greater opportunities for those who follow us. In this volume, I hope you find these fascinating and novel research efforts both thought-provoking and motivating. The advances made in reproductive medicine as presented in this volume mirror the exciting advances in many areas of science. These findings provide the basis for continued advances in patient care. •Fox and colleagues identified the genes inhibited by ibuprofen that regulate androgen production in theca cells. •Man and colleagues characterized the role of insulin-like growth factor 1 (IGF1) on follicular growth and maturation.•Fan and colleagues obtained viable follicles from deceased donors. •Harner and colleagues identified embryos with altered growth but normal metabolic function after ovulation induction.•Logsdon and colleagues characterized the TMRW vapor phase cryostorage platform in extended human embryo culture.•Rana and colleagues developed a novel annexin A5 M2 haplotyping test for use in in vitro fertilization. •Ryan and colleagues characterized the impact of delta-9-tetrahydrocannabinol on menstruation and reproductive health.•Noushin and colleagues characterized the role of platelet rich plasma on implantation in women with recurrent pregnancy failure. •Cross and colleagues determined the interaction between AKAP-13 and vitamin D regulation in leiomyoma cells. As you may know, we have surpassed the required number of peer-reviewed original manuscripts required for submission of our application to obtain PMID numbers for all prior and future articles, and have completed all the required work for consideration by PubMed. We expect to herald the next volume with full PubMed recognition for F&S Science. In fact, PubMed has released the first set of articles, which you can find by searching “F S Sci.” While this represents a small achievement in the grand scheme of our journal, we recognize that it is important for all investigators as they submit articles, and we will work diligently to achieve this accolade for all of our articles.

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