Abstract
Excessive fructose intake is known to increase serum uric acid concentrations. In an important study by Mosca et al. a large cohort of children and adolescents with proven NAFLD (37% with NASH) were studied. Hyperuricemia was present in 47% of patients with NASH compared with 29% of non-NASH patients. Importantly, both uric acid concentration and fructose consumption were independently associated with NASH, after adjustment for multiple confounders. Fructose consumption was the only factor independently associated with serum uric acid concentration. This study suggests that excessive fructose consumption could lead to hyperuricemia and contribute to NASH development in young populations. Public health policies aimed at preventing excessive fructose-containing beverages among children are warranted.
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