Abstract

On October 20, 1999, the Advisory Committee on Immunization Practices (ACIP) reviewed information about thimerosal in vaccines and received updates from CDC's National Immunization Program and several vaccine manufacturers on the current and anticipated availability of vaccines that do not contain thimerosal as a preservative. The review was prompted by a joint statement about thimerosal issued July 8, 1999, by the American Academy of Pediatrics (AAP) and the Public Health Service (PHS) (1) and a comparable statement released by the American Academy of Family Physicians (2). These statements followed a Congressionally mandated Food and Drug Administration (FDA) review of mercury in drugs and food, which included a reassessment of the use of thimerosal in vaccines.

Highlights

  • CARDIOVASCULAR DISEASE, INCLUDING coronary heart disease and stroke, is the leading cause of death in the United

  • Selection of laboratories was based on the type of method used for Hcy testing: high-performance liquid chromatography (HPLC), gas chromatography-mass spectrometry (GC-MS), and immunoassay

  • Three methods performed best regarding analytical precision: GC-MS, fluorescence polarization immunoassay (FPIA), and HPLC with fluorometric detection using a water-soluble phosphine as reducing agent (TCEP) and SBD-F as fluorescent tag

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Summary

Assessment of Laboratory Tests for Plasma

CARDIOVASCULAR DISEASE, INCLUDING coronary heart disease and stroke, is the leading cause of death in the United. Interlaboratory and intralaboratory (i.e., between tests run in a laboratory) variation was expressed as a relative standard deviation.* In the absence of target values for the samples analyzed, the GC-MS method was considered arbitrarily as a reference method. Because it used stable-isotopically labeled Hcy as an internal standard, this method is considered to be the most accurate and precise assay available. One HPLC method (HPLC with fluorescent detection using trialkylphosphine as a reducing agent and ABD-F as a labeling agent) produced results that were on average

FPIA method and the two remaining
FROM THE CENTERS FOR DISEASE CONTROL AND PREVENTION
This action was based on reports to the
United States
Contain Thimerosal as a Preservative
Influenza Vaccine
Findings
Cigarette Smoking
Full Text
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