Abstract
From the Centers for Disease Control and Prevention. Availability of Work-Related Lung Disease Surveillance Report, 1999
Highlights
In December 1994 and January 1997, articles in MMWR described a cluster of10* infants from Cleveland, Ohio, with acute idiopathic pulmonary hemorrhage, referred to as pulmonary hemosiderosis.[1,2] The children resided in seven contiguous postal tracts and had had one or more hemorrhagic episodes, resulting in one death, duringJanuary 1993-December 1994
The hypothesis from the findings of the investigation was that infant pulmonary hemorrhage may be caused by exposure to potent mycotoxins produced by S chartarum or other fungi growing in moist household environments.[4,5]
S chartarum was not clearly associated with AIPH: 1. The working group found that the reported odds ratio (OR)[4] of 9.8 for a change of 10 colony-forming units (CFU) per m3 was statistically unstable and potentially inflated
Summary
A REVIEW WITHIN CDC AND BY OUTside experts of an investigation of acute pulmonary hemorrhage/hemosiderosis in infants has identified shortcomings in the implementation and reporting of the investigation described in MMWR1,2 and detailed in other scientific publications authored, in part, by CDC personnel.[3,4,5] The reviews led CDC to conclude that a possible association between acute pulmonary hemorrhage/ hemosiderosis in infants and exposure to molds, Stachybotrys chartarum, commonly referred to by its synonym Stachybotrys atra, was not proven. This report describes the specific findings of these internal and external reviews
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