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Abstract
Introduction: Polyuria is a sign for many disease processes, including diabetes mellitus and diabetes insipidus. Urine osmolarity helps distinguish osmotic diuresis caused by diabetes mellitus from water dieresis induced by diabetes insipidus. Case Presentation: We report a case of a 48-year-old woman who presented with polyuria, polydipsia, nocturia, and weight loss after a return from a visit to Russia, during which she received a five-day course of antibiotic Demeclocycline, a tetracycline derivative for dental treatment. She recovered from all clinical manifestations by 8 weeks. Conclusion: Manifestation of transient nephrogenic diabetes insipidus is induced by Demeclocycline.
Highlights
IntroductionUrine production of more than 3 L/d, results from excretion of non-absorbable solutes (osmotic diuresis) or over-excretion of water (water diuresis) [1]
Polyuria is a sign for many disease processes, including diabetes mellitus and diabetes insipidus
Water diuresis occurs secondary to central diabetes insipidus caused by inadequate secretion of antidiuretic hormone (ADH) or nephrogenic diabetes insipidus due to failure of renal tubules to respond to circulating ADH with excretion of extremely dilute urine with osmolality < 250 mosm [1]
Summary
Urine production of more than 3 L/d, results from excretion of non-absorbable solutes (osmotic diuresis) or over-excretion of water (water diuresis) [1]. Osmotic diuresis ensues due to elevated urine osmolality usually >300 mosm/l on collection of large amounts of solutes in the renal tubules, major solutes being glucose in diabetes mellitus and mannitol and radiocontrast media administered exogenously [1]. Water diuresis occurs secondary to central diabetes insipidus caused by inadequate secretion of antidiuretic hormone (ADH) or nephrogenic diabetes insipidus due to failure of renal tubules to respond to circulating ADH with excretion of extremely dilute urine with osmolality < 250 mosm [1]. We describe a rare occurrence of nephrogenic diabetes insipidus triggered by administration of antibiotic, demeclocyline.
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