Abstract
The development of insecticide resistance is becoming a threat to many arboviruses control programs worldwide. While this has been attributed to the indiscriminate use of insecticide, a more theoretical study is apparently not available. Using in-silico experiments, we investigated the effects of two different policies: one used by the Brazilian Ministry of Health (which follows the World Health Organization protocol) and a more permissive one, akin to those employed by various gated communities and private companies. The results show that the public policy does not lead to resistance fixation. On the other hand, permissive application of adulticide, such as intensive domestic use mainly during epidemic periods, might lead to the fixation of a resistant population, even when resistance is associated with moderate fitness costs.
Highlights
The threat posed by Aedes aegypti is increasing worldwide
The objective of the present study was to examine and evaluate the effect of different strategies of chemical control of adult vectors by pyrethroids on the spread of resistance: the conservative procedure adopted by the Brazilian Ministry of Health (MoH), which is in accordance with the World Health Organization (WHO) recommendations, and a most extreme application, such as the one depicted above for gated communities during epidemic situations in major urban centres of the country
We present a series of results that were obtained through in-silico experiments using the model given by Eq (1) together with the parameters described in Mathematical model
Summary
The threat posed by Aedes aegypti is increasing worldwide. This mosquito, already recognized as the main vector of urban yellow fever and dengue, has been associated to outbreaks of other arboviruses infections. These include chikungunya and Zika which are spreading throughout several countries [1]. In Brazil, for instance, the dengue virus is present uninterruptedly since 1986 and its four serotypes circulate in the country since 2010 [3]. The chikungunya virus was introduced in 2014 and soon after, the Zika virus [4,5,6]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
