Abstract
Imagine a clinical pharmacologist administering a new competitive antagonist at muscarinic receptors to a healthy volunteer. The effects are dramatic. Mydriasis and loss of accommodation, sedation, and hallucinations occur within minutes, a tachycardia develops with a shortened PR interval on the electrocardiogram, the skin becomes dry, and the body temperature rises; the volunteer complains of a very dry mouth. The clinical pharmacologist observes these effects with considerable interest but without concern.
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