Abstract
OPINION article Front. Cell. Neurosci., 26 June 2013Sec. Cellular Neurophysiology https://doi.org/10.3389/fncel.2013.00096
Highlights
OVERVIEW OF ADULT HIPPOCAMPAL NEUROGENESIS The dentate gyrus represents a unique system for the study of interactions between neuronal development and experience
In this Opinion piece, we present the argument that mature dentate granule neurons are synaptically silent under low-stress conditions, but are recruited in far greater numbers under emotionally salient conditions due to their combined input from the amygdala and entorhinal cortex
Sparse activation of functionally mature dentate granule cells is sufficient for recall of contextual fear memory (Liu et al, 2012), suggesting that the proportion of mature granule cells recruited by an experience may be relatively small, the selective recruitment of specific ensembles is involved in the behavioral expression of memory for stressful contexts
Summary
OVERVIEW OF ADULT HIPPOCAMPAL NEUROGENESIS The dentate gyrus represents a unique system for the study of interactions between neuronal development and experience. Functional activation of the far more numerous mature granule cell population could potentially serve as an emotional tag linking spatial context with stressful experiences. The functional significance of dentate neurogenesis is thought to arise from the distinct synaptic properties of newly generated neurons, with the assumption that increased excitability among new neurons favors their recruitment over the mature dentate granule neuron population.
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