From pathophysiological aspects towards unravelling the neurobiological background of cognitive deficits

Peter Falkai,Hans-Jürgen Möller

doi:10.1007/s00406-012-0324-9

Abstract

From pathophysiological aspects towards unravelling the neurobiological background of cognitive deficits

Highlights

Evidence-based medicine is supposed to be a conclusive summary of available empirical knowledge on certain medical issues and as such serving as the basis of guidelines and treatment recommendations
In comparing the full scales HAMD17 and the Inventory of Depressive Symptomatology (IDS-C28) plus diverse unidimensional subcales in a randomised, placebo-controlled trial in a representative patient sample, Helmreich et al [2] found the full scales outmatching subscales and the IDS to be superior to the Hamilton Depression Rating Scale (HAMD) in detecting symptom changes
Kahl et al [4] have examined the prevalence of the metabolic syndrome in 230 male and female inpatients with unipolar major depressive disorder compared to 1,673 controls from primary care from a similar northern German region using the AHA/NHBLI criteria to determine rate and each single criterion of the metabolic syndrome

Summary

Introduction

Evidence-based medicine is supposed to be a conclusive summary of available empirical knowledge on certain medical issues and as such serving as the basis of guidelines and treatment recommendations. In comparing the full scales HAMD17 and the Inventory of Depressive Symptomatology (IDS-C28) plus diverse unidimensional subcales in a randomised, placebo-controlled trial in a representative patient sample, Helmreich et al [2] found the full scales outmatching subscales and the IDS to be superior to the HAMD in detecting symptom changes.

Results

Conclusion